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Back then, I went from playing Eternal Darkness to playing the GCN remake of the first Resident Evil. It was not a good transition at all for me, with what I considered to be terrible controls, a less interesting storyline (as well as a less interesting place to explore), annoying item management, and limited number of saves. I don't know how much RE4 has improved on some of the shortcomings of the series, but IMO, ED was a far better game than RE1.
RE4 lets you save as many times as you want, but you need to find a save point (a typewriter).

Item management was changed. Rather than "six items and that's it" you have a suitcase that you have to play pseudo-tetris with to hold anything you want to store.

The controls were still awkard, but nowhere in the ball park of RE1. The camera is situated over Leon's right shoulder, making the "right and left turn the character" thing a little more tolerable, but still clunky.

I remember where I stopped on RE1. First I beat up that zombie that was eating the dead guy, the one you had to beat with a knife, more than likely just barely avoiding death in the process. Then I had just gotten Jill's gun, and encountered two zombies on opposite sides of a room with a hole in the middle. I opened fire on one. The first bullet hit, but the next nine all missed. Chris Redfield is an idiot. 7-ish years before, a news crew armed with a cigarette lighter, a camcorder and a vacuum cleaner fought off hordes of animated armor and ghosts and mutant dogs and pus-spewing cutlass-wielding naked men, and he can't hit a fucking zombie standing ten feet from him with a gun.