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Since the Ulyaoth guardians take so many hits to kill, I found myself avoiding battle with them whenever possible.
I thought the guardians were unbeatable altogether (sans the one you fight as Max). I remember shooting the Xel'lotath one where all the sealed doors are with a Chattur'gha enchanted Elephant Gun about thirty times (don't recall if I had it set to fire one or two bullets. Probably two, because I went through almost all of my bullets) and it was still teleporting around and making barriers and summoning zombies. I restarted, shot it once to get it out of the way of the door to the amplifier, then ran.